Plasma cell meningitis: a rare neurological complication of multiple myeloma requiring a high index of suspicion.

PURPOSE Plasma cell meningitis is an uncommon neurologic complication of multiple myeloma with a very poor prognosis (median overall survival of 3 months). CASE REPORT We describe a previously heavy treated 54-year-old caucasian female with Bence Jones multiple myeloma who developed, shortly after a good partial response to a third line therapy, a plasma cell meningitis. Intrathecal chemotherapy was give with achievement of a complete response and improvement of her neurologic status, being alive after more than 6 months of follow-up. CONCLUSION A high index of suspicion is necessary to diagnose this rae entity since treatment initiation may provide symptomatic relief and improve the quality of life.